Anti-CD31 [JC70]
Catalogue Number: AB01338-10.3-BT-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | PECAM1; Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; GPIIA'; PECA1; JC/70A |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg |
| Host name: | Human |
| Clone: | JC70 |
| Isotype: | IgG1 |
| Immunogen: | This antibody was raised by immunising Balb/c mice with membrane preparation from a spleen affected by hairy cell leukaemia. |
| Application: | FACS, FC, IF, WB, IHC |
Additional Text
Gene Name
PECAM1
Gene ID
5175
Uniprot ID
P16284
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Application Notes
This antibody recognises CD31 which is widely expressed on endothelial cells (Parums et al., 1990) and JC70 is a good marker of endothelial cells in paraffin sections. It may be used in the identification and characterisation of benign and malignant human vascular disorders (Parums et al., 1990). For instance, one group utilised this antibody to analyse formalin-fixed paraffin-embedded rat heart tissue in a study investigating relation between cisplatin and oxidative stress (Stojic et al., 2018). Similarly, another group labelled pancreatic tumour tissue samples against CD31 while studying factors influencing development of pancreatic cancer-associated thrombosis (Woei-A-Jin et al., 2016). Finally, Kandemir and colleagues (2012) stained formalin-fixed and paraffin-embedded samples of cutaneous Kaposi sarcoma in order to characterise its immunohistochemical profile.
Short Description
This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
AB01338-10.3-BT Datasheet
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