Anti-LRP Light Chain [5A6]

Catalogue Number: AB01380-10.3-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	low density lipoprotein receptor-related protein; LRP-85; LRP1; alpha-2-macroglobulin receptor; A2MR; APR; apolipoprotein E receptor; APOER; cluster of differentiation 91; CD91; LRP-1; 85 kDa light chain of LRP
Shipping Condition:	Blue Ice
Unit(s):	200 ug
Host name:	Human
Clone:	5A6
Isotype:	IgG1
Immunogen:	This antibody was raised by immunising mice with human LRP, purified by affinity chromatography from detergent placenta extracts.
Application:	WB, IB

Overview
Datasheets

Additional Text

Gene ID

4035

Uniprot ID

Q07954

Gene Name

LRP1

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.

Application Notes

The specificity of this antibody has been confirmed in immunoblotting experiments (Strickland et al, 1990) and Western blot analysis (Mikhailenko et al, 2001). This antibody, when radiolabelled, has been used in cellular internalisation assays using CHO cells transfected with various receptors (Mikhailenko et al, 2001) and HT1080 fibrosarcoma cells transfected with MT1-MMP (Rozanov et al, 2004). This antibody has also been used in immunoblotting analysis of murine brain samples (Billings et al, 2007), murine vascular smooth muscle cells (Lehti et al, 2009), murine bone-marrow-derived macrophages (Chen et al, 2017) and human amnion epithelium and mesoderm samples (Lee et al, 2010). Additionally, it has been used in Western blot analysis of the CXCR3:LRP1 complex from human glioma cells and coronary artery smooth muscle cells (Boye et al, 2017). This antibody does not inhibit LRP-mediated internalisation of activated alpha2-macroglobulin, nor affect the binding of activated alpha2-macroglobulin to immobilised LRP (Mikhailenko et al, 2001).

Short Description

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.

AB01380-10.3 Datasheet

Price

£390.00

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