Anti-VISTA [13F3]
Catalogue Number: AB01420-22.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | PD-1H; V-domain Ig suppressor of T cell activation; V-type immunoglobulin domain-containing suppressor of T-cell activation; Platelet receptor Gi24; V-set domain-containing immunoregulatory receptor; V-set immunoregulatory receptor; Vsir; Dies1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Armenian Hamster |
| Clone: | 13F3 |
| Isotype: | IgG |
| Immunogen: | This antibody was raised by immunising Armenian hamsters with EL4 cells overexpressing VISTA-RFP, and VISTA-Ig fusion protein. |
| Application: | ELISA, FC, Blk |
Additional Text
Uniprot ID
Q9D659
Gene ID
74048
Purification
Purified
Gene Name
VSIR
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
The specificity of this antibody has been confirmed in both ELISA and flow cytometry (Wang et al, 2011). This antibody has been used in flow cytometric analysis to assess VISTA expression in murine lupus models (Ceeraz et al, 2017; Sergent et al, 2018) and mice infected with HSV-1 (Srivastava et al, 2018). This antibody has been shown to block VISTA, and enhances T cell proliferation in vitro (Wang et al, 2011). In mice models, this antibody exacerbates experimental autoimmune encephalomyelitis (Wang et al, 2011) and murine arthritis and lupus disease progression (Sergent et al, 2018). The use of this antibody to achieve a VISTA blockade enhances anti-tumour immune responses in mice models of both transplantable and inducible melanoma, suppressing tumour growth (LeMercier et al, 2014).
AB01420-22.0 Datasheet
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