Anti-SARS-CoV S glycoprotein [1B5]
Catalogue Number: AB01665-11.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | Spike protein; S protein; SARS-CoV S protein; S glycoprotein; E2; Peplomer protein; Spike protein S1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Human |
| Clone: | 1B5 |
| Isotype: | IgG2 |
| Immunogen: | The original antibody was generated by immunizing a non human transgenic animal XENOMOUSE® IgG2k mice against S1 protein-Ig fragments (ectodomain) of the S Protein (Tor2). |
| Application: | ELISA, NT |
Additional Text
Uniprot ID
P59594
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
This antibody inhibits the association of SARS-CoV s protein to the angiotensin-converting enzyme 2 (ACE2) receptor by binding to specific amino acids on the S1 domain of the spike protein of the virus. The originally characterized antibody had a neutralizing titer 200TCID50 of 12.5 µg/ml (Coughlin et at.,2006) and IC50 of 2.84 µg/ml when incubated with S12-510- Fc recombinant protein (Coughlin et at.,2009). Purified 1B5 binds to RBD region with a unique CDR3 sequence. When used in combination with 4D4 the lack of synergistic effect indicated that the mAbs 4D4 and 1B5 likely interact with closely positioned conformational epitopes and compete with each other for binding (Coughlin et at.,2009). ELISA.
AB01665-11.0 Datasheet
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