Anti-SARS-CoV S glycoprotein [1B5]

Catalogue Number: AB01665-15.0-BT-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	Spike protein; S protein; SARS-CoV S protein; S glycoprotein; E2; Peplomer protein; Spike protein S1
Shipping Condition:	Blue Ice
Unit(s):	500 ug
Host name:	Human
Clone:	1B5
Isotype:	IgM
Immunogen:	The original antibody was generated by immunizing a non human transgenic animal XENOMOUSE® IgG2k mice against S1 protein-Ig fragments (ectodomain) of the S Protein (Tor2).
Application:	ELISA, NT

Overview
Datasheets

Additional Text

Uniprot ID

P59594

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.

Application Notes

This antibody inhibits the association of SARS-CoV s protein to the angiotensin-converting enzyme 2 (ACE2) receptor by binding to specific amino acids on the S1 domain of the spike protein of the virus. The originally characterized antibody had a neutralizing titer 200TCID50 of 12.5 µg/ml (Coughlin et at.,2006) and IC50 of 2.84 µg/ml when incubated with S12-510- Fc recombinant protein (Coughlin et at.,2009). Purified 1B5 binds to RBD region with a unique CDR3 sequence. When used in combination with 4D4 the lack of synergistic effect indicated that the mAbs 4D4 and 1B5 likely interact with closely positioned conformational epitopes and compete with each other for binding (Coughlin et at.,2009). ELISA.

Short Description

This reformatted human antibody was made using the variable domain sequences of the original Human IgG2 format, for improved compatibility with existing reagents, assays and techniques.

AB01665-15.0-BT Datasheet

Price

£2,215.00

-

Quantity
Unit Size

Find out about delivery