Anti-CD154 [IDEC-131 (Toralizumab)]

Catalogue Number: AB01678-10.0-BT-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	CD40L; gp39; TRAP; Tumor necrosis factor ligand superfamily member 5; TNFSF5; T-cell antigen Gp39; TNF-related activation protein; TNF-related activation protein
Shipping Condition:	Blue Ice
Unit(s):	1 mg
Host name:	Human
Clone:	IDEC-131 (Toralizumab)
Isotype:	IgG1
Immunogen:	The original monoclonal antibody was generated by immunization with a soluble fusion protein of human gp39 (gp39-CD8).
Application:	IF, Blk

Overview
Datasheets

Additional Text

Uniprot ID

P29965

Gene Name

CD40LG

Gene ID

959

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.

Application Notes

This antibody binds CD154 with an binding affinity of Kd = 5.6 nM for theoriginally characterized antibody (Brams et al., 2001)/ Phase I clinical trials of the antibody in pateints with systemic lupus ezythematoses revealed that a single intravenous infusion at doses of 0.05-15.0 mg/kg is safe and well tolerated in patients. (Davis et al., 2001). Although, no further development for this indication has been reported since the disclosure of disappointing phase II results in April 2000. In January 2001, phase II trials in psoriasis and idiopathic thrombocytopenic purpura (ITP) were initiated. By january 2002, a phase II trial in Crohn's disease was also ongoing. (Dumont FJ, 2002) Ab IDEC-131 was tested alone and in combination with rapamycin and DST for its ability to inhibit rhesus MLRs and it was seen that therapy with IDEC-131, rapamycin, and DST induced long-term allograft survival without intermittent acute rejection.(He Xu et, al., 2003) IDEC-131 was also used in a comparative study using 3 monoclonal antibodies αCD40 (2C10R4) and αCD154 (5C8H1 and IDEC-131 to check CD40/CD154 T cell costimulation pathway in a non-human primate cardiac allotransplant model (O'Neill et al., 2017) Other suitable use in ELISA, FC, IF, IP.

AB01678-10.0-BT Datasheet

Price

£1,655.00

-

Quantity
Unit Size

Find out about delivery