Anti-Plakophilin 1 [10B2]

Catalogue Number: AB01693-10.3-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	PKP1; PKP-1; Plakophilin-1; Band 6 protein; B6P; PKP 1
Shipping Condition:	Blue Ice
Unit(s):	200 ug
Host name:	Human
Clone:	10B2
Isotype:	IgG1
Immunogen:	This antibody was raised by immunizing mice with the N-terminus of human Plakophilin-1 protein.
Application:	FC, IF, IP, WB, IHC

Overview
Datasheets

Additional Text

Uniprot ID

Q13835

Gene ID

5317

Gene Name

PKP1

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.

Application Notes

10B2 is recommedned for the detection and analysis of Plakophilin-1. In order to identify potential perturbations in cell adherence, this antibody was used to detect plakophilin-1 in the skin tissue of patients with epidermolysis bullosa via immunofluorescence (Pigors et al., 2011; pmid: 21320868). Further, this antibody was demonstrated to have a potential diagnostic role in certain diseases, such as Ectodermal Dysplasia/Skin Fragility Syndrome where it was used to differentiate between a diseased and healthy skin samples (Sprecher et al., 2004; pmid: 15086548). It was also shown that 10B2 antibody can detect plakophilin-1 (PKP1) via Western blot (here: in HaCaT protein lysates) (Bonne et al., 2003; pmid: 12707304).

Short Description

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

AB01693-10.3 Datasheet

Price

£390.00

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