Anti-ICOS [3F12]
Catalogue Number: AB01701-201.1-BT-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | CD278; Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; Inducible co-stimulator; Inducible costimulator; caICOS; canine ICOS; dog ICOS |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg |
| Host name: | Dog |
| Clone: | 3F12 |
| Isotype: | IgG2 |
| Immunogen: | This antibody was raised by immunizing RBF/DnJ mice with caICOS-murine-IgG2a fusion and hybridomas were generated using accepted methods. |
| Application: | ELISA, FC, Blk |
Additional Text
Gene Name
ICOS
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Uniprot ID
Q7YR73
Gene ID
403456
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Application Notes
3F12 can be used to identify canine ICOS and analyse its activity. The antibody is an antagonist of ICOS and exhibits the ability to significantly suppress mixed leukocyte reactions (MLR) (Sato et al., 2013; pmid: 23694952). Anti-ICOS antibody was also shown to be an effective agent that can be used in the treatment development of Canine Chronic Graft-versus-Host Disease (GVHD) (Graves et al., 2017; pmid: 28958896).
Short Description
This chimeric dog antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
AB01701-201.1-BT Datasheet
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