Anti-Spike protein (RBD) [Sb#68]
Catalogue Number: AB02017-1.159-BT-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg |
| Host name: | Mouse |
| Clone: | Sb#68 |
| Isotype: | IgG1 |
| Immunogen: | This clone was originally isolated in a form of a synthetic nanobody (sybody) via a 'target swap' selection procedure against RBD-vYFP using ribosomal display and against RBD-Fc fusion during phage display rounds. |
| Application: | ELISA, Inh |
Additional Text
Gene Name
S
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Gene ID
43740568
Uniprot ID
P0DTC2
Specificity
SARS CoV 2 S glycoprotein; Sb68; COVID-19 Spike protein; RBD; Receptor Binding Domain; E2 glycoprotein; E2; Human coronavirus 2 spike glycoprotein; Peplomer protein; S glycoprotein; SARS coronavirus 2 S protein; SARS coronavirus 2 Spike Protein; SARS CoV 2 Spike protein; SARS CoV 2; SARS-CoV-2 S protein; SARSCoV2; SARS-COV-2 S protein; SARS-COV-2 Spike glycoprotein; SARSCOV2 Spike protein; Severe acute respiratory syndrome 2 spike glycoprotein; Severe acute respiratory syndrome virus 2 spike glycoprotein; Spike glycoprotein; 2019-nCoV; SARS-CoV2
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Application Notes
This antibody is recommended for detection of SARS CoV 2 or 2019-nCoV. Sb#68 is a strong binder and binds the 2019-nCoV ectodomain with an affinity of KD ~ 37 nM (Walter et al., 2020). The initial characterization and binding activity of this antibody to SARS CoV2 spike protein was confirmed with ELISA (Walter et al., 2020). This antibody is a mild inhibitor for interaction between hACE2 and RBD of SARS CoV2. This clone binds to a non-overlapping epitope relative to S#15 (Ab02013) what can be used in develoepment of anti-Covid-19 therapuetics granting together increased avidity to the spike protein (Walter et al., 2020).
Short Description
This chimeric mouse antibody was made using the variable domain sequences of the original VHH format, for improved compatibility with existing reagents, assays and techniques.
AB02017-1.159-BT Datasheet
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