Anti-Spike Protein [CV1]
Catalogue Number: AB02018-44.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | S-protein; SARS-CoV2; SARS Coronavirus 2; SARS-CoV-2; SARS CoV 2; 2019-nCoV; Severe acute respiratory syndrome coronavirus 2; Spike protein; S protein; SARS-CoV 2 S protein; S glycoprotein; E2; Peplomer protein; SARS-CoV2 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Host name: | Cat |
| Clone: | CV1 |
| Isotype: | IgM |
| Immunogen: | The original antibody was generated by isolating B-cells from the peripheral blood mononuclear cells (PBMCs) of SARS CoV2 infected patients, after the serum neutralizing activity was confirmed. |
| Application: | ELISA, FC, NT |
Additional Text
Gene Name
S
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Gene ID
43740568
Uniprot ID
P0DTC2
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
This antibody is recommended for diagnosis and/or treatment of SARS CoV 2 or 2019-nCoV. CV1 binds an epitope outside the SARS CoV 2 RBD was found to be weakly neutralizing (IC50=15µg/ml). ELISA was used to confirm the binding of SARS CoV 2 positive serum samples to the entire ectodomain and the receptor binding domain of the spike protein. Specific binding of the mAb to SARS CoV 2 to ectodomain was confirmed with biolayer interferometry. Phycoerythrin labelled mAb was used to stain 293E cells transfected with wild type SARS CoV 2 and were analysed by flow cytometry (Seydoux et al., 2020).
Short Description
This chimeric cat antibody was made using the variable domain sequences of the original human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
AB02018-44.0 Datasheet
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