Anti-FGF1 [1C9]
Catalogue Number: AB02035-10.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | FGF-1; aFGF; ECGF; HBGF-1; Fibroblast growth factor 1; Acidic fibroblast growth factor; Endothelial cell growth factor; Heparin-binding growth factor 1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Human |
| Clone: | 1C9 |
| Isotype: | IgG1 |
| Immunogen: | The original antibody was generated by immunizing mice with human FGF-1. |
| Application: | ELISA, IF, IP, WB, IHC |
Additional Text
Gene Name
FGF1
Uniprot ID
P05230
Gene ID
2246
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
FGF-1 plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Studies have shown that FGF-1 is overexpressed in the early stages of several kinds of cancer. Functional analysis showed that the overexpressed scFv1C9 in MCF-7 cells targeted endogenous FGF-1 and prevented the translocation of FGF-1 into the nucleus, resulting in the blockade of the intracrine pathway of FGF-1, which caused the G1 arrest by p21 up-regulation. Binding of scFv1C9 to FGF-1 was confirmed with ELISA. The antigen-binding ability of scFv1C9 with endogenous FGF-1 was confirmed in vivo by using of an immunoprecipitation assay. FGF-1 immunohistochemical staining of breast ductal carcinoma tissues was used to to demonstrate that FGF-1 was increasingly expressed in breast cancer tissues.(PMID:21360642).
Short Description
This full-length, chimeric human antibody was made using the variable domain sequences of the original Mouse scFv format, for improved compatibility with existing reagents, assays and techniques.
AB02035-10.0 Datasheet
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