Anti-17-Hydroxyprogesterone [57 (57.G6.1)]

Catalogue Number: AB02042-10.3-BT-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	17-OH; 17-OHP; 17α-hydroxyprogesterone
Shipping Condition:	Blue Ice
Unit(s):	1 mg
Host name:	Human
Clone:	57 (57.G6.1)
Isotype:	IgG1
Immunogen:	The original antibody was generated by immunizing BALB/c mice with 17-OHP-bovine serum albumin conjugate as an immunogen.
Application:	ELISA, RIA

Overview
Datasheets

Additional Text

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.

Application Notes

This antibody binds 17-OHP, a chemical intermediate involved in the biosynthesis of many endogenous steroids like androgens, estrogens, glucocorticoids, and mineralocorticoids, as well as neurosteroids. Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder caused by the deficiency of one of the five enzymes involved in the biosynthesis of corticosteroids. The most common form of the disease is the deficiency of 21-hydroxylase that catalyses the production of cortisol. Due to lack of this enzyme there is an accumulation of high levels of 17α-hydroxyprogesterone (17-OHP). This antibody is therefore recommended for detection of high levels of 17-OHP caused by CAH. Fluorescence enzyme immunoassay and micro-enzyme immunoassay for 17-OHP was used to test the cross reactivity of this antibody with other steroids (PMID: 3312820).

Short Description

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.

AB02042-10.3-BT Datasheet

Price

£1,655.00

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