Anti-Progesterone [11/32]
Catalogue Number: AB02043-10.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | P4; pregn-4-ene-3,20-dione |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Human |
| Clone: | 11/32 |
| Isotype: | IgG1 |
| Immunogen: | The original antibody was generated by immunizing BALB/c mice with 11-α-hydroxyprogesterone-11-hemisuccinyl-bovine serum albumin (BSA) conjugate. |
| Application: | RIA, Blk |
Additional Text
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
This antibody binds progesterone, which is an endogenous steroid female sex hormone, involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. The hormone is produced by the corpus luteum in the ovaries and later by the placenta during pregnancy and is necessary for maintenance of pregnancy as it prevents the breakdown of the endometrium. This antibody against progesterone may be used for the study its role in the female reproductive system and uring pregnancy. It may also be used as an immunological prevention of pregnancy. The antibody is reported to have blocking effects and prevention of pregnancy in mice (PMID:7057905). Passive immunization of mice with this antibody has anti-fertility effects by blocking implantation (PMID:2373979, 3411286). This antibody is also reported to cross react with other steroids (PMID: 3123368, 7632616).
Short Description
This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
AB02043-10.0 Datasheet
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