Anti-Spike protein [Sb23]

Catalogue Number: AB02062-1.159-BT-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Shipping Condition:	Blue Ice
Storage Condition:	2-8°C
Unit(s):	500 ug
Host name:	Mouse
Clone:	Sb23
Isotype:	IgG1
Immunogen:	The original antibody was
Application:	ELISA, NT, BLI

Overview
Datasheets

Additional Text

Gene Name

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Gene ID

43740568

Uniprot ID

P0DTC2

Specificity

SARS CoV 2 S glycoprotein; Sb23; COVID-19 Spike protein; RBD; Receptor Binding Domain; E2 glycoprotein; E2; Human coronavirus 2 spike glycoprotein; Peplomer protein; S glycoprotein; SARS coronavirus 2 S protein; SARS coronavirus 2 Spike Protein; SARS CoV 2 Spike protein; SARS CoV 2; SARS-CoV-2 S protein; SARSCoV2; SARS-COV-2 S protein; SARS-COV-2 Spike glycoprotein; SARSCOV2 Spike protein; Severe acute respiratory syndrome 2 spike glycoprotein; Severe acute respiratory syndrome virus 2 spike glycoprotein; Spike glycoprotein; 2019-nCoV

Storage Note

Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.

Application Notes

Sb23 binds RBD with a very high affinity and neutralizes pseudovirus with an IC50 of 0.6 µg/ml. Sb23 and ACE2 compete for the same or overlapping binding sites on SARS-CoV-2-RBD. ELISA was used to screen the libraries to identify specific RBD binders. It is also reported that since Sb23 can efficiently replace ACE2 from a preformed complex, it has a higher affinity for RBD than ACE2. Biolayer interferometry assay was used to kinetically characterize the interaction of sybodies with RBD and spike (Custodio et al., 2020).

Short Description

This chimeric mouse antibody was made using the variable domain sequences of the original VHH format, for improved compatibility with existing reagents, assays and techniques.

AB02062-1.159-BT Datasheet

Price

£2,190.00

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