Anti-Canine Lymphoma [Mab231]
Catalogue Number: AB02092-201.1-BT-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | Canine Lymphoma 17-71 |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 1 mg |
| Host name: | Dog |
| Clone: | Mab231 |
| Isotype: | IgG2 |
| Immunogen: | The original antibody was generated by immunizing BALB/c mice with cannine lymphoma cell line 17-71. |
| Application: | FC, RIA |
Additional Text
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Application Notes
This antibody is recommended for detection of canine lymphoma cells. The binding ability of the hybridoma supernatents with canine lymphoma cells was determined by radioimmunoassay. FACS analysis was used to analyse the binding of the antibody to cells freshly isolated from canine lymphomatous nodes and normal lymphocytes of canine and human blood (Steplewski et al., 1987). This antibody has been shown to exhibit antibody-dependent cellular cytotoxicity as well as complement-dependant cytolysis (Rosales et al., 1988). Canine lymphoma is conventionally treated with chemotherapy, but it was found that subsequent treatment with a specific monoclonal antibody, Mab 231, raised against the lymphoma, substantially prolonged remission and survival times (Jeglum, 1989).
Short Description
This chimeric dog antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
AB02092-201.1-BT Datasheet
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