Anti-HA [CR6261]
Catalogue Number: AB02199-44.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | Hemagglutinin; Avian Influenza Virus; AIV; H1N1; H5N1; Influenza A virus |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Host name: | Cat |
| Clone: | CR6261 |
| Isotype: | IgM |
| Immunogen: | The original antibody was isolated using phage display from the IgM+ memory B cells of a healthy individual vaccinated against influenza. |
| Application: | NT |
Additional Text
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
UniProt ID
Q9WFX3
Application Notes
The antibody neutralizes the virus by blocking conformational rearrangements associated with membrane fusion. CR6261 neutralizes multiple influenza subtypes, including H1, H2, H5, H6, H8, and H9, and protects mice from lethal challenge with H1N1 and H5N1 viruses when administered up to five days post-infection (PMID: 19251591). It is reported that Oseltamivir/Zanamivir may congruously improve the therapeutic efficacy of CR6261 (PMID: 22693576).
Short Description
This chimeric human antibody was made using the variable domain sequences of the original Alpaca VHH format, for improved compatibility with existing reagents, assays and techniques.
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DELIVERY
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