Anti-HA [AV.C4]
Catalogue Number: AB02203-44.0-BT-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | Hemagglutinin; Avian Influenza Virus; AIV; H5N1; H5N2; H5N3; Influenza A virus |
| Shipping Condition: | Blue Ice |
| Unit(s): | 500 ug |
| Host name: | Cat |
| Clone: | AV.C4 |
| Isotype: | IgM |
| Immunogen: | The original antibody was isolated from human semi-synthetic ETH-2 phage antibody library by biopanning against H5 hemagglutinin. |
| Application: | ELISA, WB, NT |
Additional Text
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Uniprot ID
A5A5M5
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Application Notes
The specificity of this scFv antibody for binding H5 type of hemaglutinin was determined by ELISA. AV.C4 binds a conserved epitope shared by three different virus strains belonging to the H5 subtype, i.e. the homologous strain A/Vietnam/ 1194/04 (H5N1), and two viruses isolated form wild birds, A/Nammalr/Italy/80/93 (H5N2) and A/Mallard/Italy/208/00 (H5N3). This antibody does not cross react with H1N1 influenza virus. scFv clone AV.C4 exerted a significant inhibition of the H5N1 A/Vietnam/1194/2004 virus infection in a pseudotype-based neutralization assay. This antibody was capable of detecting a 70kDa protein corresponding to the uncleaved HA protein in a western blot assay (PMID: 19481117).
Short Description
This chimeric mouse antibody was made using the variable domain sequences of the original Llama sdAB format, for improved compatibility with existing reagents, assays and techniques.
AB02203-44.0-BT Datasheet
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