Anti-CD80 [B7-24]
Catalogue Number: AB02229-10.0-BT-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg |
| Host name: | Human |
| Clone: | B7-24 |
| Isotype: | IgG1 |
| Immunogen: | The original antibody was generated by fusion with splenocytes from a mouse immunized with Sf9 insect cells expressing the human B7 molecule. |
| Application: | FC, IP, IHC |
Additional Text
Gene Name
CD80
Gene ID
941
Uniprot ID
P33681
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Specificity
BB1; B7; B7-1; B7.1; CD28LG; CD28LG1; LAB7; Activation B7-1 antigen; T-lymphocyte activation antigen CD80; CTLA-4 counter-receptor B7.1; B-lymphocyte activation antigen B7; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); costimulatory factor CD80; costimulatory molecule variant IgV-CD80 ; CTLA4L; CTLA-4L
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Application Notes
This mAb binds to a functionally important epitope of the B7 molecule. B7-24 is not able to inhibit T cell proliferation in primary mixed lymphocyte reactions where purified T cells are co-cultured with Epstein-Barr virus-transformed B cells. This antibody was used to study the cell surface expression of B7 antigen using flow cytometry. This antibody was also able to immunoprecipitate radioactive Iodine-labeled EBV-transformed B cells (PMID: 1280221). This antibody was used to examine the in situ expression of B7/BB1 by immunohistochemistry (PMID: 7682106).
Short Description
This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
AB02229-10.0-BT Datasheet
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