Anti-Disialoganglioside 2 [3G6]
Catalogue Number: AB02232-10.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | GD2 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Human |
| Clone: | 3G6 |
| Isotype: | IgG1 |
| Immunogen: | The original antibody was generated by immunizing BALB/c mice with human neuroblastoma cells. |
| Application: | ELISA, FC, IF, RIA |
Additional Text
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
The binding studies of this antibody to various human tissues was done using ELISA and indirect immunofluorescence. This antibody also showed comparable reciprocal cross-blocking in radioimmunoassay on LAN-1 NB cells or NB glycolipid extracts (PMID: 2580625). This antibody is also recommended for the study of distribution of the GD2 antigen on various types of cancer tissues. This antibodhy was also used in the development of a chimeric receptor 3G6-CD28, which provides CD28 signaling upon specific recognition of the GD2 antigen on tumor cells (PMID: 9705944). Expression of GD2 expressing cells was done by flow cytometry using 3G6. This antibody was also used in anti-GD2 therapy to test the survival and metastasis after challenge with EL4 cells (PMID: 16288049).
Short Description
This chimeric human antibody was made using the variable domain sequences of the original Mouse IgM format, for improved compatibility with existing reagents, assays and techniques.
AB02232-10.0 Datasheet
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