Anti-CD66b [BW 250/183]
Catalogue Number: AB02238-10.3-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | CEACAM8; CGM6; Carcinoembryonic antigen-related cell adhesion molecule 8; Carcinoembryonic antigen CGM6; CD67 antigen; Non-specific cross-reacting antigen; NCA-95 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Human |
| Clone: | BW 250/183 |
| Isotype: | IgG1 |
| Immunogen: | The original antibody was generated by immunizing mice with CEA positive adenocarcinoma cells preferably from lungs. |
| Application: | FC, ICC, IF |
Additional Text
Gene ID
1088
Uniprot ID
P31997
Gene Name
CEACAM8
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
This murine antibody reacted with granulocytes, colon mucosa and faintly with pancreatic ducts (PMID: 2410375). The radioactive isotope technetium-99m labelled version of this antibody is also called Besilesomab (trade name Scintimun). It has been studied widely for therapeutic applications. Technetium-99m-Labeled BW 250/183 was used to study the inflamatory process and identification of the inflamatory foci using immunoscintigraphy (PMID: 2157831, 1565572). This antibody is also used for scintiographic imaging of soft tissue infections, peripheral bone, and abdominal infections (PMID: 8023170). Tc-99m-labeled antibody has also been used in the localization of extramedullary hematopoiesis (PMID: 11953571). Rhenium-188-labelled BW250/183 was developed for adjuvant conditioning radioimmunotherapy of bone marrow before bone marrow transplantation. Immunoreactivity of the reduced and rhenium-incorporated antibody was determined by indirect immunofluorescence, by means of a whole blood staining method follwoed by flow ctometric analysis (PMID: 10541824). 90Y-label is reportedled antibody is reported to be used in the study of expression of CD66b in non-Hodgkin lymphomas and multiple myeloma usinf flow cytometry (PMID: 20887387).
Short Description
This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
AB02238-10.3 Datasheet
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