Anti-CXCR4 [I-3859 ]
Catalogue Number: AB02396-10.3-BT-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg |
| Host name: | Human |
| Clone: | I-3859 |
| Isotype: | IgG1 |
| Immunogen: | The original antibody was generated by immunizing BALB/c mice with recombinant NIH3T3-CXCR4 cells and/or peptides corresponding to CXCR4 extracellular N-term and loops. |
| Application: | ELISA, FC, IP, IHC |
Additional Text
Gene Name
CXCR4
Uniprot ID
P61073
Gene ID
7852
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Specificity
CD184; CXC-R4; CXCR-4; FB22; Fusin; HM89; LCR1; LESTR; LAP-3; C-X-C chemokine receptor type 4; Leukocyte-derived seven transmembrane domain receptor; Lipopolysaccharide-associated protein 3; LPS-associated protein 3; NPYRL; Stromal cell-derived factor 1 receptor; SDF-1 receptor
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Application Notes
The binding of this antibody to human CXCR4 was tested using ELISA. This antibody is capable of immunoprecipitating both CXCR4 monomers and dimers. I-3859 can also recognize CXCR4 present on NIH3T3-hCXCR4 transfected cells, MDA-MB-231,U937 promyelocytic cancer cells and Hela cervix cancer cells by flow cytometry. This antibody is also found to compete with other Anti-CXCR4 mAb 515H7 for binding to cell membrance as analyzed by flow cytometry. This antibody can be used for the immunohistochemical staining of tumor cells expressing CXCR4. It was used for the staining of RAMOS and KARPAS299 xenograft tumor cells (US20140170677).
Short Description
This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
AB02396-10.3-BT Datasheet
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations