Anti-Notch 1 [N248A]
Catalogue Number: AB02406-1.1-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | Notch1; hN1; TAN-1; Neurogenic locus notch homolog protein 1; Translocation-associated notch protein TAN-1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Mouse |
| Clone: | N248A |
| Isotype: | IgG1 |
| Immunogen: | The original antibody was generated by immunizing BALB/c mice with recombinant notch 1 fusion protein as immunogen. The fusion protein contained N-terminal leader peptide, EGF-like repeats 35 to 36, NRR (including Lin A, B and C domains and the HD domain) and a small portion of intracellular sequence. |
| Application: | ELISA, Blk |
Additional Text
Gene Name
NOTCH1
Uniprot ID
P46531
Gene ID
4851
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
This antagonist antibody binds notch 1 with an affinity of Kd= 0.33 nM. The binding epitopes of Notch 1 antibody was analyzed by domain swap and ELISA binding assays. mAb N248A inhibits both T-cell acute lymphoblastic leukemia (T-ALL) and breast cancer cell growth in cell culture. N248A also inhibits T-cell lymphoblastic leukemia in murine xenograft tumor model (WO2012080891).
AB02406-1.1 Datasheet
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