Anti-CD89 [14A8 (14.1)]

Catalogue Number: AB02426-10.0-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	Immunoglobulin alpha Fc receptor; FCAR; IgA Fc receptor; FcαR
Shipping Condition:	Blue Ice
Unit(s):	200 ug
Host name:	Human
Clone:	14A8 (14.1)
Isotype:	IgG1
Immunogen:	The original antibody was generated by immunizing HCO12 trangene containing mice with recombinant soluble CD89 antigen.
Application:	ELISA, FC, IP

Overview
Datasheets

Additional Text

Gene Name

FCAR

Uniprot ID

P24071

Gene ID

2204

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.

Application Notes

This antibody binds human CD89 with a dissociation constant of Kd= 6.8 X10-10M.The binding of this antibody to human CD89 was confirmed with ELISA. This antibody was also capable of recognizing human CD89 expressing cells like human PMNL cells by flow cytometry. This antibody is not capable of blocking binding of IgA to CD89. This antibody can used to immunoprecipitate soluble CD89 (US7192582). A bispecific antibody construct incorporating the variable regions of the anti-gp41 antibody F240 and the anti-CD89 (immunoglobulin A [IgA] receptor) antibody 14A8 was reported to promote destruction of HIV type 1 (HIV-1) by neutrophils (PMID: 18272577). A Fab-like bispecific antibody molecule or Bi-Fab antibody generated from F240scFv and 14A8scFv showed significant antiboy dependent cell-mediated viral inhibition (ADCVI) activity for multiple clade B and clade C isolates by arming the neutrophils to inhibit HIV infection (PMID: 27419146).

Short Description

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

AB02426-10.0 Datasheet

Price

£390.00

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