Anti-PD-L2 [24F.10C12]
Catalogue Number: AB02439-2.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | CD273; PDL2; PDCD1LG2; PDCD1L2; PD-1 ligand 2; PDCD1 ligand 2; PDCD1 ligand 2; Programmed cell death 1 ligand 2; Butyrophilin B7-DC; B7-DC |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Mouse |
| Clone: | 24F.10C12 |
| Isotype: | IgG2a |
| Immunogen: | |
| Application: | ELISA, FC, IHC, Blk |
Additional Text
Uniprot ID
Q9BQ51
Gene ID
80380
Gene Name
PDCD1LG2
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
This antibody can recognize PD-L2-Fc in an ELISA. Flow cytometric analysis with whole anti-PD-L2 mAb 24F.10C12 and its Fab version revealed approximately the same mean fluorescence intensity upon binding PD-L2 transfected cells. This antibody is capable of blocking the binding of PD-1-Ig to PD-L2 in a dose-dependent manner and with high avidity. This antibody was also used for the immunohistochemical studies of various tissues including thymus, germinal center, placenta, cardiac tissues, and tumors. Blockade of PD-L2 on dendritic cells results in enhanced T cell proliferation and cytokine production, including that of IFN-gamma and IL-10. Both the whole antibody version and Fab version enhanced T cell activation, showing that PD-L2 functions to inhibit T cell activation (PMID: 12538684). This antibody was used for the study of PD-1 pathway on the activation of naive, memory, and recently activated human CD4+ T cells (PMID: 15598424). Antibody blockade of endothelial cell PD-L2 enhanced endothelial cell costimulation of PHA-activated human CD8+ T cells (PMID: 14579280).
AB02439-2.0 Datasheet
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