Anti-PD-L2 [24F.10C12]

Catalogue Number: AB02439-2.3-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	CD273; PDL2; PDCD1LG2; PDCD1L2; PD-1 ligand 2; PDCD1 ligand 2; PDCD1 ligand 2; Programmed cell death 1 ligand 2; Butyrophilin B7-DC; B7-DC
Shipping Condition:	Blue Ice
Unit(s):	200 ug
Host name:	Mouse
Clone:	24F.10C12
Isotype:	IgG2a
Immunogen:
Application:	ELISA, FC, IHC, Blk

Overview
Datasheets

Additional Text

Uniprot ID

Q9BQ51

Gene ID

80380

Gene Name

PDCD1LG2

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.

Application Notes

This antibody can recognize PD-L2-Fc in an ELISA. Flow cytometric analysis with whole anti-PD-L2 mAb 24F.10C12 and its Fab version revealed approximately the same mean fluorescence intensity upon binding PD-L2 transfected cells. This antibody is capable of blocking the binding of PD-1-Ig to PD-L2 in a dose-dependent manner and with high avidity. This antibody was also used for the immunohistochemical studies of various tissues including thymus, germinal center, placenta, cardiac tissues, and tumors. Blockade of PD-L2 on dendritic cells results in enhanced T cell proliferation and cytokine production, including that of IFN-gamma and IL-10. Both the whole antibody version and Fab version enhanced T cell activation, showing that PD-L2 functions to inhibit T cell activation (PMID: 12538684). This antibody was used for the study of PD-1 pathway on the activation of naive, memory, and recently activated human CD4+ T cells (PMID: 15598424). Antibody blockade of endothelial cell PD-L2 enhanced endothelial cell costimulation of PHA-activated human CD8+ T cells (PMID: 14579280).

AB02439-2.3 Datasheet

Price

£390.00

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