Anti-CCR2 [AbAb-CCR2]

Catalogue Number: AB02444-8.1-BT-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	CD192; C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; Monocyte chemoattractant protein 1 receptor; MCP-1-R; JE/FIC receptor; CMKBR2
Shipping Condition:	Blue Ice
Unit(s):	1 mg
Host name:	Rat
Clone:	AbAb-CCR2
Isotype:	IgG2b
Immunogen:	The original antibody was generated by immunizing rats with CHO cells stably transfected with mouse CCR2.
Application:	FC, Blk

Overview
Datasheets

Additional Text

Gene Name

CCR2

Uniprot ID

P51683

Purification

Purified

Gene ID

12772

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.

Application Notes

This antibody can be used to detect mouse CCR2 expressed on the surface of CHO cells and mouse peripheral blood leukocytes using flow cytometry. This antibody is capable of reducing the activity of murine monocyte chemotactic protein 1 in a manner similar to the well characterized anti-CCR2 antibody MC-21. This antibody can prevent the influx of monocytes in thioglycolate-induced peritonitis. This antibody is also capable of blocking the binding of mouse CCR2 with its ligand in vitro and in vivo. The blockade of CCR2 with this antibody also impairs monocytes/macrophage recruitment in vivo. This antibody can be used to determine the role of chemokine receptor CCR2 during initiation and progression of collagen induced arthritis in mice using blocking antibodies. This antibody is capable of abolishing long-term behavioral recovery after ischemic stroke and drastically decreased tissue expression of anti-inflammatory genes, including TGFβ, CD163, and Ym1.

AB02444-8.1-BT Datasheet

Price

£1,655.00

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