Anti-HER3 [A5 ]
Catalogue Number: AB02460-23.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | ERBB3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3; HER3.A5 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Rabbit |
| Clone: | A5 |
| Isotype: | IgG |
| Immunogen: | The original antibody was created using phage display from large naive human scFv libraries. |
| Application: | FC, SPR |
Additional Text
Gene Name
ERBB3
Gene ID
2065
Uniprot ID
P21860
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
A5 scFv binds to ErbB3 ECD with a KD of 1.6 x 10-7 M. The ability to bind HER3 was assesed in this antibody using surface plasmon resonance. An anti ErbB2/ErbB3 bispecific antibody made from ML3-9 and A5 clones called the A5-linker-ML3.9 bs-scFv exhibits selective targeting of tumour cells in vitro and in vivo that co-express the two target antigens over tumour cells that express only one target antigen or normal cells that express low levels of both antigens. This study was done using flow cytometry. (Robinson et al, 2008;pmid:18841159).
Short Description
This full-length, chimeric rabbit antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.
AB02460-23.0 Datasheet
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