Anti-HER2 [ML3-9 (C6ML3-9)]
Catalogue Number: AB02462-23.0-BT-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | CD340; ERBB2; MLN 1; NEU; NGL; Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; p185HER2; ML3.9; C6ML3.9 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg |
| Host name: | Rabbit |
| Clone: | ML3-9 (C6ML3-9) |
| Isotype: | IgG |
| Immunogen: | The original antibody was created using phage display from large naive human scFv libraries. |
| Application: | FC, RIA, SPR |
Additional Text
Gene ID
2064
Gene Name
ERBB2
Uniprot ID
P04626
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Application Notes
This antibody is an affinity matured version of the parent scFv antibody C6.5 (Schier et al,1996;pmid: 8918938). The ML3-9 scFv binds to the ErbB2 ECD with a KD of 1.1 nM. Another clone derived from ML3-9 An radioimmunoassay was performed on human serum using this antibody. The ability to bind HER2/neu was assesed in this antibody using surface plasmon resonance. An anti ErbB2/ErbB3 bispecific antibody made from ML3-9 and A5 clones called the A5-linker-ML3.9 bs-scFv exhibits selective targeting of tumour cells in vitro and in vivo that co-express the two target antigens over tumour cells that express only one target antigen or normal cells that express low levels of both antigens. This study was done using flow cytometry (Robinson et al, 2008;pmid:18841159).
Short Description
This full-length, chimeric rabbit antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.
AB02462-23.0-BT Datasheet
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