Anti-ICOS ligand [Clone 323]
Catalogue Number: AB02476-10.3-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | CD275; ICOSLG; ICOSL; B7-H2; B7H2; B7RP-1; B7RP1; KIAA0653; B7 homolog 2; B7-like protein GL50; B7-related protein 1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Human |
| Clone: | Clone 323 |
| Isotype: | IgG1 |
| Immunogen: | The original antibody was isolated from a human naive scFv phage library and panning against B7RP-1-Fc protein. |
| Application: | ELISA, FC, Blk, Inh |
Additional Text
Uniprot ID
O75144
Purification
Purified
Gene ID
102723996; 23308
Gene Name
ICOSLG, LOC102723996
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
The scFv version of this antibody binds B7RP-1-Fc with a Kd= 9nM. The binding specificity of this antibody was confirmed using ELISA. This scFv version of this antibody was shown to bind B7RP-1-Fc in an ELISA. This antibody recognized B7RP-1 molecules expressed on B cells, as assessed by flow cytometry. This antibody is capable of inhibiting interaction between ICOS-Fc and B7RP-1-Fc. This antibody also exhibited inhibitory activity in a proliferation assay of T cells stimulated with anti-CD3 mAb and B7RP-1-Fc (PMID: 20065650).
Short Description
This full-length, reformatted human antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.
AB02476-10.3 Datasheet
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