Anti-EpCAM [MOC31]
Catalogue Number: AB02660-10.3-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Human |
| Clone: | MOC31 |
| Isotype: | IgG1 |
| Immunogen: | The original antibody was generated by immunizing mice with human EGP-2 antigen. |
| Application: | ELISA, FC, IHC, SPR |
Additional Text
Gene ID
4072
Gene Name
EPCAM
Uniprot ID
P16422
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Specificity
CD326; Ep-CAM; KS1/4 antigen; KSA; Epithelial cell adhesion molecule; Adenocarcinoma-associated antigen; Cell surface glycoprotein Trop-1; Epithelial cell surface antigen; Epithelial glycoprotein; EGP; Epithelial glycoprotein 314; 17-1A-antigen; EGP314; hEGP314; Major gastrointestinal tumor-associated protein GA733-2; Tumor-associated calcium signal transducer 1; EGP-2; EGP40; KSA; CO17-1A; GA733-2; MOC-31
Application Notes
The binding affinity of this antibody for human EpCAM was determined using surface plasmon resonance and ELISA. The scFv version of this antibody was used to immunohistochemically stain human carcinoma cells, colonic epithelium, colon carcinoma and melanoma (PMID: 9836471). This antibody binds EpCAM-positive Kato III cell line in a flow cytometric assay. The IgG2a format of this antibody was used for the immunohistochemical analysis of normal human tissues and cancerous tissues. In immunohistochemical studies, MOC31 showed binding towards colon cancers, breast cancer and lung cancer with epithelial origin (PMID: 24525727). This antibody is also reported to be used in differentiation between adenocarcinoma and reactive mesothelial cells (PMID: 10603193). This antibody was also used for immunohistochemical staining of adenocarcinomas (PMID: 16329115).
Short Description
This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
AB02660-10.3 Datasheet
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