Anti-CD127 [GR34]
Catalogue Number: AB02672-23.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | IL7R; IL7Rα; IL-7Rα; Interleukin-7 receptor subunit alpha; IL-7 receptor subunit alpha; IL-7R-alpha; IL-7RA; CDw127 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Rabbit |
| Clone: | GR34 |
| Isotype: | IgG |
| Immunogen: | The original parental clone was generated by immunizing BALB/c mice with Pre-Alp, a t(l;19) pre-B leukemic cell line. |
| Application: | ELISA, Blk, Ant |
Additional Text
Gene ID
3575
Uniprot ID
P16871
Gene Name
IL7R
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
This IL-7R antagonist antibody is a recombinant engineered version of clone R34.34. The binding affinity of this antibody for human IL-7R was checked using ELISA. Antibody GR34 (mouse IgG1 version) was determined to inhibit pSTAT5 signalling with an IC50of 0.22µg/ml. The mouse IgG1 version had an affinity for the IL-7Rα EDC of 15.3nM (KD) and a Kd of 8.75X10-4. The mouse IgG1 version was capable of binding to IL-7Rα expressed on CHO cells with an EC50 of 0.27µg/ml, and blocked IL-7/IL-7Rα with an IC50of 2.29µg/ml (WO2010017468).
Short Description
This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
AB02672-23.0 Datasheet
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