Anti-Collagen type II [M2139]

Catalogue Number: AB02802-3.3-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	M2 139; CII; Col II; CollA; ACPA; COL2A1; citrullinated CII; Col C II; citrullinated proteins; antibodies against citrullinated proteins; Collagen alpha-1(II) chain; Alpha-1 type II collagen
Shipping Condition:	Blue Ice
Unit(s):	200 ug
Host name:	Mouse
Clone:	M2139
Isotype:	IgG2b
Immunogen:	The original antibody was generated by immunizing DBA/1 mice with chicken or rat CII.
Application:	ELISA, IHC, Blk, InVivoA

Overview
Datasheets

Additional Text

Gene Name

COL2A1

Uniprot ID

P02458

Gene ID

1280

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.

Application Notes

Epitope localization of the original format of this antibody (mouse IgG2b) was conducted using ELISA (Schulte et al., 1998; PMID: 9430695). this antibody, in combination with CIIC1, was utilized to induce collagen type II (Col II) antibody-induced arthritis in vivo in mice (Nandakumar et al., 2003; PMID: 14578183). This combination has later been shown to be potently arthritogenic in vivo, affecting cartilage matrix integrity in cartilage explant cultures, impairing synthesis of new matrix, and disrupting collagen fibril formation in chondrocyte cultures (Croxford et al., 2013; PMID: 23239042). Moreover, this antibody was employed in a study to investigate whether mAb CIIF4, when given in combination with this antibody and CIIC1, can prevent cartilage damage in bovine cartilage explants in vitro (Croxford et al., 2010; PMID: 20662051). The original version of this antibody was utilized to examine the production of collagen II with IHC staining (Gharravi et al., 2016; PMID: 26254592) and in the immunohistochemical staining of Col II (Soetjahjo et al., 2018; PMID: n/a).

AB02802-3.3 Datasheet

Price

£390.00

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