Anti-HIV-1 GP120 [VRC03]
Catalogue Number: AB02806-23.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | Glycoprotein 120; SU; surface protein gp120; env polyprotein; envelope glycoprotein gp16 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Rabbit |
| Clone: | VRC03 |
| Isotype: | IgG |
| Immunogen: | The original antibody was generated from human B cells obtained from an HIV infected donor. |
| Application: | ELISA, NT, SPR |
Additional Text
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Uniprot ID
P35961
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
The binding profile of this antibody towards HIV-1 GP120 was studied using ELISA and surface plasmon resonance. The original VRC03 IgG1 antibody, successfully neutralizes over 50% of current circulating HIV-1 isolates. (Mascola et al., US8637036). This antibody was reported to bind the resurfaced stabilized core 3 (RSC3) of the mutated HIV-1 envelop glycoprotein that is also capable of binding CD4. The original IgG1 version of this antibody has a binding affinity of KD = 7.31 x 10-8 M. (PMID: 20616233). VRC03 was found to potently inhibit entry into CD4+ T cells of HIV isolated from the latent viral reservoir of infected individuals whose plasma viremia was well controlled by antiretroviral therapy (ART) (PMID: 25157148).
Short Description
This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.
AB02806-23.0 Datasheet
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations