Anti-Integrin alpha V [17E6]

Catalogue Number: AB02953-23.0-BT-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	272-17E6; Vitronectin receptor; Vitronectin receptor subunit alpha; CD antigen: CD51; Integrin alpha-V heavy chain; Integrin alpha-V light chain
Shipping Condition:	Blue Ice
Unit(s):	1 mg
Host name:	Rabbit
Clone:	17E6
Isotype:	IgG
Immunogen:	The original antibody was generated by immunizing BALB/c mice with of purified placental αvβ3.
Application:	ELISA, FACS, FC, IP

Overview
Datasheets

Additional Text

Gene Name

ITGAV

Gene ID

3685

Uniprot ID

P06756

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.

Application Notes

αv-Integrin is an integral membrane protein involved in cell adhesion. Antibody screening by ELISA revealed the antibody reacted specifically with αvβ3. In ELISA on fixed cells ('CELISA') the antibody showed a reaction pattern consistent with its recognition of the αv integrin chain (cells expressing αvβ3 and αvβ5 (M21)). The ability of the antibody to recognize native αv integrins was tested by FACS analysis, where the αv-expressing cells (M21) reacted strongly with the antibody. Immunoprecipitation from surface labelled cells showed the antibody detected αv integrin in M21 cells. Furthermore, αv-integrins can function as receptors for vitronectin. However, the antibody had the ability to disrupt stable interaction between vitronectin and αvβ3, and blocked the growth of M21 tumors in nude mice.

Short Description

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.

AB02953-23.0-BT Datasheet

Price

£1,655.00

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