Anti-Oligodendrocyte-specific surface antigen [sHIgM22 (LYM22)]
Catalogue Number: AB02987-15.0-BT-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | oligodendrocyte |
| Shipping Condition: | Blue Ice |
| Unit(s): | 500 ug |
| Host name: | Human |
| Clone: | sHIgM22 (LYM22) |
| Isotype: | IgM |
| Immunogen: | The original antibody was isolated from the sera obtained from 102 patients with a wide variety of conditions including Waldenstrom's macroglobulinemia, multiple myeloma, lymphoma, and monoclonal gammopathy. |
| Application: | ICC, IF, IHC |
Additional Text
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Application Notes
This antibody is directed against the cell surface antigen of oligodendrocyte and induces calcium signals in cultured glial cells promotes and promotes significant remyelination in a virus mediated mouse model of multiple sclerosis (MS). A single 0.5 mg peripheral dose of either of two human IgMs (sHIgM22 and sHIgM46) promoted significant remyelination in chronically Theiler's murine encephalomyelitis virus (TMEV) infected mice (PMID: 10841576). This antibody was also found to accelerate the rate of remyelination of axons in a lysolecithin-induced demyelination mouse model (PMID: 11857682). This antibody was used in the immunohistochemical staining of mature mouse cerebellar slices and was found to bind the white matter also react with Purkinje cells in the granular layer (PMID: 12154009). A recombinant IgM version of this antibody (rHIgM22) was generated and tested for its ability to induce remyelination in the Theileris virus mouse model of chronic-progressive demyelinating disease (PMID: 12154009). This antibody can be used for the immunofluorescent staining of oligodendrocytes, as well as to central white matter of the cerebellum (PMID: 14655764). This antibody was also used in the immunohistochemical and immunocytochemical analysis of active MS lesions from 83 biopsies and autopsies of MS patients and was also used in the identification of four different pathologic subtypes of active MS lesions (PMID: 21961063)
AB02987-15.0-BT Datasheet
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations