Anti-Cn2 toxin [BCF2]
Catalogue Number: AB03040-23.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | scorpion toxin; Beta-mammal toxin Cn2; Toxin 2; Toxin II.9.2.2; scorpion venom |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Rabbit |
| Clone: | BCF2 |
| Isotype: | IgG |
| Immunogen: | The original antibody was generated by immunizing female BALB/c mice with a conjugate comprising thyroglobulin and a fraction II-9.2 (which contains toxins 2 and 3) of the Centruroides noxius (mexican scorpion) venom in Freund's complete adjuvant. |
| Application: | ELISA, RIA, NT |
Additional Text
Purification
Purified
Uniprot ID
P01495
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
The binding specificity and characterization of this antibody towards Cn2 toxin of scorpion Centruroicles noxius was tested using ELISA and RIA. This antibody was capable of inhibiting binding of C. noxius toxin 2 to rat brain membranes in vitro and neutralizing the toxin acitivity in vivo in mice (PMID: 1371253). It was reported that the Fab fragment of this antibody was capable of neutralizing both the Cn2 toxin and whole soluble venom of scorpion Centruroides noxius (PMID: 8875771). The scFv version of this atnbidoy did not shoe any neutralization acitivity in vivo due to its less stability (PMID: 15713481).
Short Description
This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
AB03040-23.0 Datasheet
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