Anti-Arginase 1 [mAb1]
Catalogue Number: AB03082-2.0-BT-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | ARG1; Arginase-1; Liver-type arginase; Type I arginase |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg |
| Host name: | Mouse |
| Clone: | mAb1 |
| Isotype: | IgG2a |
| Immunogen: | The antibody is a human antibody identified via yeast display technologies and isolated after panning against arginase 1. |
| Application: | EM, Inh |
Additional Text
Gene Name
ARG1
Gene ID
383
Uniprot ID
P05089
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Application Notes
The structure and epitope mapping of the complex arginase:antibody was determined by cryo-electron microscopy. The antibody was assessed for its potency and extent of inhibition of human arginase using an assay that detects the formation of thioornithine from thioarginine. In this assay, as well as an LCMS assay, it was determined that the antibody could fully inhibit the enzymatic activity of arginase. To assess the kinetic mechanism of inhibition of the antibody, increasing fixed concentrations of antibody were tested across a range of thioarginine concentrations. The Ki for the antibody against human Arg1 was 3.3 +/- 0.3 nM (Palte et al., 2021; PMID: 34326456).
AB03082-2.0-BT Datasheet
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