Anti-TIGIT [nb66]
Catalogue Number: AB03139-34.11-BS-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | VSTM3; VSIG9; WUCAM; T-cell immunoreceptor with Ig and ITIM domains; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain-containing protein 3 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg |
| Host name: | Camelid |
| Clone: | nb66 |
| Isotype: | |
| Immunogen: | The original antibody was generated by immunizing camels with human-derived TIGIT extracellular segment as antigen to obtain a high-quality immune nanobody gene library. The library was panned against human TIGIT to obtain this antibody. |
| Application: | ELISA, FC, Blk |
Additional Text
Uniprot ID
Q495A1
Gene ID
201633
Gene Name
TIGIT
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Application Notes
The binding characterization of this antibody towards human and cynomolgus monkey TIGIT was done using ELISA. It was reported that this antibody is capable of blocking the interaction of TIGIT with CD155 on the surface of CT26 cells. This antibody can recognize human TIGIT expressed on CHOZN/TIGIT cells in a flow cytometry. Epitope mapping of this antibody suggested that this antibody binds an epitope similar to that of another anti-TIGIT antibody called Tiragolumab. This antibody in combination with another anti-TIGIT antibody NB49 was used in the development of a bi-epitope bivalent antibody and its was reported that the blocking activity of the bi-epitope antibodies Nb49-Nb66 was significantly improved compared to the single antibody and the control antibody (CN111718415).
AB03139-34.11-BS Datasheet
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