Anti-E protein [Mab 4.2]

Catalogue Number: AB03170-1.1-BT-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	tick-borne encephalitis virus; TBEV; LIV; Envelope protein Domain III
Shipping Condition:	Blue Ice
Unit(s):	1 mg
Host name:	Mouse
Clone:	Mab 4.2
Isotype:	IgG1
Immunogen:
Application:	ELISA, IF, NT, InVivoA, SPR, Crstion

Overview
Datasheets

Additional Text

Purification

Purified

Antibody Clonality

Recombinant Monoclonal

Gene Name

POLY

Gene ID

1489719; 1724640

Storage Note

Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.

UniProt ID

P14336, P22338

Application Notes

The antibody prevented mice against challenge with a lethal dose of LIV (Gao et al., 1994; PMID: 8126456). The specificity of the scFv fragment for LIV antigen was confirmed by ELISA analysis. Immunofluorescence was performed on PS cells infected with LIV or TBEV using the scFv and the original antibody. The antibody and the scFv fragment could neutralize both LIV and TBEV (Jiang et al., 1994; PMID: 8128623). The binding affinities of the scFv fragment for LIV E and for TBEV E were measured by surface plasmon resonance (respectively 45.4 nM and 390 nM for LIV and TBEV E). The structures of the scFv fragment in complex with the envelope protein from either TBEV or LIV were determined. The antibody showed potential as a therapeutic agent (Yang et al., 2019; PMID: 30760569).

AB03170-1.1-BT Datasheet

Price

£1,655.00

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