Anti-E Cadherin [56-4]
Catalogue Number: AB03205-23.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | CD324; ARC-1; Cdh1; Cadherin-1; Cadherin E; E-Cadherin; Uvomorulin |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Rabbit |
| Clone: | 56-4 |
| Isotype: | IgG |
| Immunogen: | The original antibody was generated by immunizing rabbits with purified extracellular domain of mouse E-cadherin. |
| Application: | ELISA, Agon |
Additional Text
Gene Name
CDH1
Gene ID
12550
Uniprot ID
P09803
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
The binding of this antibody to mouse E-cadherin results in its activation. The initial binding characterization of this antibody to mouse E-cadherin was done using ELISA. This antibody was used to study the effect of activation of mouse E-cadherin on the growth and metastasis of a spontaneous breast cancer mouse model. Female MMTV-PyMT and control mice treated with 5 mg/kg of this antibody developed tumors in all 10 mammary glands. Also the number of metastasis nodules was significantly reduced with treatment with 56-4 activating antibody (PMID: 32127478; WO2020243616).
AB03205-23.0 Datasheet
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