Anti-FcRn [h22-0015]
Catalogue Number: AB03237-10.0-BT-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | IgG receptor FcRn large subunit p51; FCGRT; IgG Fc fragment receptor transporter alpha chain; Neonatal Fc receptor |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg |
| Host name: | Human |
| Clone: | h22-0015 |
| Isotype: | IgG1 |
| Immunogen: | The original antibody was generated by immunizing Balb/c mice with recombinant FcRn. |
| Application: | Blk, InVitroA, InVivoA |
Additional Text
Gene Name
FCGRT
Uniprot ID
P55899
Gene ID
2217
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Application Notes
The antibody was employed in blocking experiments with HEK293 cells that overexpress FcRn. The results showed that the antibody has a good effect of blocking the binding of IgG to FcRn at the cellular level (IC50: 11.4nM). The effect of the antibody was tested in human FcRn transgenic mice. The antibody was able to increase IgG catabolism in vivo by blocking FcRn binding (CN113484526).
Short Description
This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
AB03237-10.0-BT Datasheet
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