Anti-beta 1 integrin [AIIB2]
Catalogue Number: AB03450-6.1-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | integrin beta 1; Integrin beta-1-binding protein 1; Integrin cytoplasmic domain-associated protein 1 (ICAP-1) |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ug |
| Host name: | Rat |
| Clone: | AIIB2 |
| Isotype: | IgG1 |
| Immunogen: | The original antibody was isolated by immunizing a Lewis rat with JAR choriocarcinoma cells. |
| Application: | FACS, FC, IP, Inh, InVivoA |
Additional Text
Gene Name
ITGB1BP1
Gene ID
9270
Uniprot ID
O14713
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
The antibody immunoprecipitated the integrin subunits (Hall et al.,1990). This antibody was used for detection of β1 integrin expressed on CHO cells by flow cytometry (Takada et al., 1993; PMID: 7688727). The original format of the antibody or its F(ab')2 fragments applied to single cells were capable of down-modulating β1 integrin signaling pathways (Wang et al., 1998; PMID: 9843973 and Weaver et al., 1997; PMID: 9105051). The antibody was used in immunofluorescence characterization of integrins in the HMT-3522 cells (Weaver et al., 1997; PMID: 9105051). The antibody inhibited tumor cell growth in several breast cancer cell lines (T4-2, MDA-MB-231, BT474, SKBR3, and MCF-7) and one nonmalignant cell line (S-1). Further, β1 integrin inhibition resulted in a significant loss of cancer cells, associated with a decrease in proliferation and increase in apoptosis, and a global change in the composition of residual colonies (Park et al., 2010; PMID: 16452209). The antibody was found to reduce the frequency of solid tumor stem cells. The antibody inhibited the growth of colon tumors and reduced the percentage of CD44+ cells. Tumors treated in mice showed a decrease when treated with the antibody. The humanized version of the antibody was constructed, showing potential for therapeutic uses (WO2009009114A3).
AB03450-6.1 Datasheet
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