Anti-F protein [mAb 338]
Catalogue Number: AB03554-16.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | Fusion glycoprotein; Protein F; hMPV F protein; hMPV fusion glycoprotein; Human metapneumovirus; 168-A5-338-284 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Host name: | Human |
| Clone: | mAb 338 |
| Isotype: | IgA1 |
| Immunogen: | The original antibody was generated by immunizing BALB/c mice with a combination of some or all of the following: intranasal infection with hMPV at 10^6 TCID50 per animal of either NL1700, NL100, or NL199; intranasal infection with 10^6 PFU b/hPIV3/hMPV FNL100; intraperitoneal injection with adenovirus-vectored hMPV FNL100 or hMPV FNL199 at a dose of 9 x 10^7 TCID50; purified soluble hMPV F protein derived from NL100 and NL199 sequences injected intraperitoneally with either GERBU MM adjuvant. |
| Application: | ELISA, NT |
Additional Text
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Gene Name
F
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Uniprot ID
Q6WB98
Gene ID
2799939
Application Notes
ELISA was used to confirm the binding of this antibody to hMPV F protein. This antibody has been reported to have high neutralizing activity against all of the hMPV types A1, A2, B1, and B2 with an in vitro IC50 of < 2µg/ml. The antibody is effective as passive prophylaxis in protecting hamsters from HMPV challenge and also reduces incidence of MPV infection and disease in animal models (PMID: 16873237). Intraperitoneal injection of thia antibody into BALB/c mice significantly decreased lung viral titers after HMPV challenge when the antibody was administered prophylactically or therapeutically (PMID: PMID: 20619294).
Short Description
This chimeric rabbit antibody was made using the variable domain sequences of the original Chicken VHH format, for improved compatibility with existing reagents, assays and techniques.
AB03554-16.0 Datasheet
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations