Anti-Gn [RV-Gn1]
Catalogue Number: AB03696-23.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | RVFV Gn; p78; Glycoprotein G1; Glycoprotein N |
| Shipping Condition: | Blue Ice |
| Unit(s): | 0.1 mg |
| Host name: | Rabbit |
| Clone: | RV-Gn1 |
| Isotype: | IgG |
| Immunogen: | The original antibody was generated by immunizing New Zealand White rabbits with the full-length RVFV Gn ectodomain. |
| Application: | ELISA, NT, InVivoA, Crstapy |
Additional Text
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
UniProt ID
P21401
Application Notes
The specificity of the original format of the antibody was confirmed by ELISA analysis.The antibody was able to able to neutralize RVFV in vitro. A plaque reduction neutralization test (PRNT) demonstrated that the antibody neutralized RVFV with half-maximal inhibitory concentration (IC50) values ranging from 2.1 to 3.0 µg/mL. The antibody protected against RVFV challenge in a murine infection model. The structure of rift valley fever virus Gn in complex with the Fab fragment of the antibody was determined, revealings that the antibody targeted to the membrane-distal head region of RVFV Gn (Allen et al., 2018; PMID: 30590046).
AB03696-23.0 Datasheet
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