Anti-SAR-55 ORF2 [HEV#31], Rabbit IgG, kappa
Catalogue Number: AB03787-23.0-BT-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | HEV; Secreted protein ORF2; Protein ORF2; pORF2 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg |
| Host name: | Rabbit |
| Clone: | HEV#31 |
| Isotype: | IgG |
| Immunogen: | A chimpanzee previously infected with specific viral pathogens was used as a source of bone marrow lymphocytes for the construction of a phage display library. The original antibody was isolated from this library. |
| Application: | ELISA, WB, RIA, NT, SPR |
Additional Text
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Application Notes
The specificity of the original format of the antibody for SAR-55 ORF2 protein and swine HEV was confirmed by ELISA analysis (Kd= 0.8 and 1.3 nM respectively). The antibody recognized reduced, denatured HEV ORF2 protein by Western Blot. The antibody strongly precipitated the construct corresponding to aa112-607 of the ORF2 protein by radioimmunoprecipitation. The binding affinity of the antibody to SAR-55 ORF2 protein was measured by surface plasmon resonance (Kd= 4.5 nM). The original antibody was able to neutralize the SAR-55 strain of HEV, as determined by intravenous challenge of rhesus monkeys (US7148323B2).
Short Description
This is a reformatted, chimeric antibody made using the variable domain sequences of the original human Fab antibody to improve compatibility with existing reagents, assays, and techniques.
UniProt ID
P33426
AB03787-23.0-BT Datasheet
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