Anti-EGFR [ML66]
Catalogue Number: AB03825-6.1-BT-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg |
| Host name: | Rat |
| Clone: | ML66 |
| Isotype: | IgG1 |
| Immunogen: | The original antibody was generated by immunizing female rats with membrane prep of MDA-MB468 breast cancer cell line. |
| Application: | FC, Inh, InVivoA |
Additional Text
Gene ID
1956
Gene Name
EGFR
Uniprot ID
P00533
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Specificity
ERBB; ERBB1; HER1; PIG61; mENA; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; epidermal growth factor receptor
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Application Notes
The humanized version of the antibody exhibited strong specific binding to both human tumor cell lines and Vero cells by flow cytometry. This original and humanized version of the antibody were used for detection of EGFR expressed on MDA-MB468 cells by flow cytometry. The humanized version of the antibody induced NK cell mediated killing of target cells in a dose dependent manner. The chML66-antibody-maytansinoid conjugates significantly deleted the tumor growth in a tumor xenograft model using EGFR expressing KB cells implanted subcutaneously in SCID mice (US20160017053A1).
AB03825-6.1-BT Datasheet
SUPPORT
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PRODUCT
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DELIVERY
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