Anti-Integrin alpha 6 beta 1 [TS2/16]
Catalogue Number: AB03837-10.0-BT-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg |
| Host name: | Human |
| Clone: | TS2/16 |
| Isotype: | IgG1 |
| Immunogen: | |
| Application: | FC, IP, InVitroA, InVivoA, Crstapy |
Additional Text
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Gene ID
3655; 3688
Gene Name
ITGA6, ITGB1
Specificity
CD29; Integrin α6β1; Integrin alpha-6/beta-1 (ITGA6:ITGB1); Integrin alpha VI beta 1; ITGA6; CD49F; Integrin alpha-6; CD49 antigen-like family member F; VLA-6; ITGB1; FNRB; MDF2; MSK12; Integrin beta-1; Fibronectin receptor subunit beta; Glycoprotein IIa; GPIIA; VLA-4 subunit beta
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
UniProt ID
P05556, P23229
Application Notes
The antibody immunoprecipitated the 130 kDa β1 form of in U87MG cells. Flow cytometry analysis performed with the antibody confirmed that it could recognise β1-A172 cells (Bartik et al., 2008; PMID: 18425328). The structure of the Fv-clasp fragment of the antibody was determined. Further, the crystal structure of the a6b1 headpiece complexed with Fv-clasp was determined (Arimori et al., 2017; PMID: 28919443). The antibody increased integrin β1 in vitro and in vivo (Ritsma et al., 2017; PMID: 28448494)
Short Description
This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
AB03837-10.0-BT Datasheet
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