Anti-M protein, serotype 5 [36.2.2]

Catalogue Number: AB03916-23.0-BT-ABA

Manufacturer:	Vector Laboratories, Inc (ABA)
Type:	Recombinant Monoclonal
Alias:	Streptococcal M-protein; Myosin; Actin; Keratin; Tropomyosin; Troponin; Laminin; Ganglioside; Glycophorin M,N
Shipping Condition:	Blue Ice
Storage Condition:	2-8°C
Unit(s):	1 mg
Host name:	Rabbit
Clone:	36.2.2
Isotype:	IgG
Immunogen:	The original antibody was generated by immunizing BALB/c BYJ mice with streptococcal M type 5 membranes followed by a second, boosting dose of M type 5 streptococcal membranes.
Application:	ELISA, IF, WB, HA, PRNT

Overview
Datasheets

Additional Text

Purification

Purified

Uniprot ID

P02977

Antibody Clonality

Recombinant Monoclonal

Storage Note

Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.

Application Notes

This antibody reacts with human heart cells and whole streptococci (group A, M type 5), as shown in an ELISA, and human heart cells, human sarcolemma, and group A streptococcal membranes, as shown in a WB (Cunnigham et al., 1984; PMID: 6384047). This antibody reacts with the heavy chain of skeletal muscle myosin. Specifically, it reacts with light meromyosin fragments, as shown in WB and competitive inhibition assays (Cunningham et al., 1986; PMID: 3510006). This antibody labels the cytoplasm of epidermal cells and epidermal appendages in normal and psoriatic skin, as shown by immunofluorescent staining (Swerlick et al., 1986; PMID: 3525693). This antibody binds CV (B3), as shown in an ELISA; neutralizes PV-1 and CV (B3), as shown in a plaque-reduction neutralization assay; and is cytotoxic to rat heart cells and fibroblasts, as shown in a cytotoxicity assay (Cunningham et al., 1992; PMID: 1311095). This antibody reacts with retinal S-antigen (S-Ag), as shown in an ELISA (Lerner et al., 1995; PMID: 8722579). This antibody was found to be cytotoxic for rat heart cells (Antone et al., 1997 ;PMID: 9548482). This antibody binds myosin at a high relative avidity, as determined in a competitive ELISA. (Mertens et al., 2000; PMID: 11282394).

Short Description

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

AB03916-23.0-BT Datasheet

Price

£1,805.00

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