Anti-M protein, serotype 5 [49.8.9]
Catalogue Number: AB03920-23.0-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | Myosin; Streptococcal M-protein; Keratin; DNA; Vimentin; Troponin; Ganglioside; Glycophorin M,N |
| Shipping Condition: | Blue Ice |
| Unit(s): | 0.1 mg |
| Host name: | Rabbit |
| Clone: | 49.8.9 |
| Isotype: | IgG |
| Immunogen: | The original antibody was generated by immunizing BALB/c BYJ mice with streptococcal M type 5 membranes followed by a second, boosting dose of M type 5 streptococcal membranes. |
| Application: | ELISA, WB, HA, PRNT |
Additional Text
Purification
Purified
Uniprot ID
P02977
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Application Notes
This antibody reacts with human heart cells and whole streptococci (group A, M type 5), as shown in an ELISA, and with human heart cells, human sarcolemma (weak response), and group A streptococcal membranes (weak response), as shown in a WB (Cunnigham et al., 1984; PMID: 6384047). This antibody labels the cytoplasm of epidermal cells and epidermal appendages in normal and psoriatic skin, as shown by immunofluorescent staining (Swerlick et al., 1986; PMID: 3525693). This antibody binds CV (B3), as shown in an ELISA; neutralizes PV-1 and CV (B3), as shown in a plaque-reduction neutralization assay; and is slightly cytotoxic to rat fibroblasts, as shown in a cytotoxicity assay (Cunningham et al., 1992; PMID: 1311095). This antibody reacts with retinal S-antigen (S-Ag), as shown in an ELISA (Lerner et al., 1995; PMID: 8722579). This antibody binds myosin at a medium relative avidity, as determined in a competitive ELISA. Reactivity with glycophorin M and N was determined by hemagglutination assay (Mertens et al., 2000; PMID: 11282394).
Short Description
This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
AB03920-23.0 Datasheet
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