Anti-TGF beta [1D11.16.8]
Catalogue Number: AB03951-10.3-BT-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 1 mg |
| Host name: | Human |
| Clone: | 1D11.16.8 |
| Isotype: | IgG1 |
| Immunogen: | The original antibody was generated by intraperitoneally (IP) injecting female Balb/c mice with 10 ug of native bovine TGF-B2 with complete Freund's adjuvant. |
| Application: | IHC-P, IP, WB, IHC, FA, NT |
Additional Text
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Gene Name
TGFB1, TGFB2, TGFB3
Gene ID
282089; 534069; 538957
Specificity
TGF-β; TGFβ; TGFB1; TGFB2; TGFB3; TGF-B1; TGF-B2; TGF-B3; TGF beta 1; TGF beta 2; TGF beta 3; CED; DPD1; LAP; Latency-associated peptide; prepro-transforming growth factor beta-1; regulatory protein; transforming growth factor; transforming growth factor beta; 1D11.16; 1D11
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
UniProt ID
A6QP91, P18341, P21214
Application Notes
This antibody was able to neutralize the biological activity of both TGF-beta 1 and beta 2 in vitro. This antibody could detect the dimeric form of TGF-beta 2 in western blots. This antibody was also reported to immunoprecipitate [125I]-TGF-beta 2 (PMID: 2537357). This antibody is also able to neutralize the growth promoting actions of TGF-B1 and B2 in the NRK proliferation assay and TGF-B induced alkaline phosphatase production in an assay using the ROS 17.2.8 osteosarcoma cell line (US5571714). This antibody was used for detection of TGF-β production in vivo in spleens sections of L. donovani-infected hamsters using immunohistochemistry (PMID: 9488418). This antibody was also used for the immunohistochemical analysis of FFPE human renal biopsy specimens for presence of TGF-beta (PMID: 10515378).
Short Description
This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
AB03951-10.3-BT Datasheet
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